Dynamic relaxometry: application to iron uptake by ferritin
نویسندگان
چکیده
منابع مشابه
Uptake and Release of Ferritin Iron
The uptake and subsequent release of iron by apoferritin and ferritin was studied by using labelled iron (59Fe). The experimental results are consistent with predictions arising from amodel system developed in the interpretation ofprevious experiments. In thismodel, uptake and release of ferritin iron is controlled by the available surface area of the small crystalline particles of hydrous ferr...
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Iron delivery to mammalian cells is traditionally ascribed to diferric transferrin (Tf). We recently reported that human erythroid precursor cells possess specific membranes receptors that bind and internalize acid isoferritin. Here we show that ferritin uptake by these cells is highly regulated and that the internalized ferritin-iron is used for home synthesis and thus, this process could cons...
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Iron uptake and release by ferritin molecules of different iron contents show similar profiles. These are discussed in relation to the structure of the ferritin molecule. Two models of iron uptake and release are considered. One involves iron oxidation-reduction sites on the protein. The other allows direct interaction of reagents with the iron-core crystallites. It is concluded that the second...
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Ferritins are iron-storage proteins that accumulate in plastids during seed formation, and also in leaves during senescence or iron overload. Iron release from ferritins occurs during growth of seedlings and greening of plastids. Depending on the concentration of the reducing agent ascorbate, either an overall iron release or uptake by ferritins from iron(III) citrate may occur. We have designe...
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ژورنال
عنوان ژورنال: JBIC Journal of Biological Inorganic Chemistry
سال: 2000
ISSN: 0949-8257,1432-1327
DOI: 10.1007/s007750050007